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KMID : 0370219870310020070
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Yakhak Hoeji
1987 Volume.31 No. 2 p.70 ~ p.81
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Immunological Studies on Antitumor Component of Lyophyllum decastes(I)
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이정옥/Lee CO
최응칠/김병각/Choi EC/Kim BK
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Abstract
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To elucidate action mechanism of lyophyllan A, an antitumor polysaccharide of Lyophyllum decastes, its immunological activities were examined. Lyophyllan A increased significantly the weights of spleen and liver of mice. Lyophyllan A also restored the decreased thymic weight in tumor-bearing mice. It did not show any direct cytotoxicity against tumor cells, but showed immunopotentiating activities by increasing the number of the plaques in hemolytic plaque assays. Lyophyllan A increased the number of peritoneal exudate cells (PEC) and inhibited the growth of sarcoma 180 mixed with PEC. Moreover the macrophages from lyophyllan A-treated mice exhibited a strong cytotoxic activity towards L5178Y target cells.
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